- Strategic Studies Group - Developers of Total War, Warlords II for the Mac, Ardennes Offence and Warlords II and III for the PC. [PC/Mac]
- Sylum Entertainment Ltd. - Developer of Deerhunter III and Sportsman's Paradise.
- Shrapnel Games - Publisher of 101st Airborne in Normandy.
- Soleau Software - Developer of family friendly non-violent strategy logic games for both Windows and Macintosh computers.
- Softgame - Developer of PC card games such as poker and solitaire.
- SoftSpot Software - Developer of intellectual word games and puzzles. Titles include Letter Rack and What's Up.
- Stardust Entertainment - Creators of platformer Myth of the Moon Stone.
- Sucker Punch Productions - Creators and developers of the Sly Cooper series of games.
- Studio 218 - Developer of games using Hyperstudio.
- Slitherine Software - Creators of Tyrannosaurus Tex for the Game Boy Color.
- SCS Software - Independent developer of Rocky Mountain Trophy Hunter 3 and Shark! Hunting the Great White.
- SoftySoft - Developer of Anarchy and Deathchase 3D.
- Smoking Gun Productions - Developer of Giant Killers and Arrival.
- Sandbox Studios - Develops children's software and arcade titles for consoles and PCs.
- Spectrum Pacific Publishing - Publisher of Case Closed.
- Studio 3 Interactive - Computer and video game publishers.
- Small Rockets - Developer of downloadable PC games such as Masters of the Sky: The Red Ace, Tower of the Ancients, and Jetboat Superchamps.
- Soft-iK - Develops Windows CE games such as Larva Run.
- Studio SAN - Developers of advertising games.
- Savoir Fair - Contains company and game information, downloads, and a forum.
- Supedo - Developer of multiplayer mobile games.
- Starbreeze Studios AB - Developers of Enclave.
- Sports Interactive - Developers of sports games such as Championship Manager, CM Quiz and an EHM.
- Sounds4games - Sells collections of sounds to game developers.
- spark - Developer of Call of Duty: Finest Hour for Playstation 2, Gamecube and Xbox.
- Semionetix - International developer and publisher of interactive entertainment software and arcade machines.
- Shin'en Multimedia - Developer of such titles as the Iridion series and Maya the Bee. Game information, Game Boy Advance sound utilities, and company information.
- Studio Gigante, Inc. - Developer of Tao Feng for the Xbox.
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